Recently, several reviews by the Cochrane Collaboration have been completed.They allow us to assess the impact of the new antipsychotics on clinically relevant outcome measures.Also, Dantrolene has some efficacy in mitigating the course of disease. The introduction of clozapine, risperidone and olanzapine has improved the outcomes for patients with psychoses.Other lab abnormalities include leukocytosis and elevated LFTs.Treatment involves stopping the med (obviously), supportive care with IVFs, cardiac monitoring, electrolyte repletion, etc.
The narrow perspective has traditionally been influenced by pharmaceutical regulatory bodies, and includes key concepts such as a reduction in positive symptoms and an acceptable adverse effect profile.
Although it is usually thought of as a chronic and progressive disease, it actually can have a variable course and improve with discontinuation of the offending med. Extrapyramidal Symptoms – again, more with conventional antipsychotics.
Sometimes responds to dose reduction or switching another medication. Can treat with beta blockers, benzos, anticholinergics, antihistamines. Metabolic Side effects (Diabetes, Hyperlipidemia, Hypertension, Weight Gain) – more common with the atypical antipsychotics, especially Clozapine. Neuroleptic Malignant Syndrome – can be a life-threatening disease that occurs with all antipsychotics, but most often with the conventional, high-potency drugs (haloperidol, fluphenazine).
Antipsychotic medications are effective in the management of acute psychotic symptoms arising from a variety of psychiatric and neuropsychiatric conditions.
In particular, antipsychotic medications (also known as neuroleptics) are effective in reducing symptoms such as delusions, hallucinations and disorganised communication.